There are intersections like 395/98 with signs that say, "ONE WAY. DO NOT ENTER" to warn people who attempt to enter the wrong side of a four-plus lane highway.
The scariest confusing intersection in ATL used to be the southbound HOV exit at Northside Drive from I-75. A bus driver carrying a load of college baseball players supposedly interpreted "HOV exit" to mean that if driving a HOV vehicle, exiting was required to stay in the HOV lane. He took the HOV exit, drove across the overpass, and the bus dropped down from the overpass onto I-75. Several kids were killed.
I just happened to be in the area the next day and drove the same path. I saw that the signage was incomplete and confusing. Wow, have they ever fixed that since then.
I can totally understand how the bus driver got confused. Not to mention that it was dark outside. It's hard enough to drive on the expressways in ATL when you were born and raised there.